Zero preventable
deaths from AKI
by 2025

0by25 - an ISN human rights initiative

Eliminating preventable deaths from Acute Kidney Injury (AKI) in three key ways:


0by25 will provide compelling new data to demonstrate the global burden of AKI, especially in low and middle-income countries, with the aim of establishing AKI as a contributor to the Global Burden of Disease. 0by25 will compile existing and prospective data in order to better understand AKI’s prevalence and to improve diagnostic and treatment methods.

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Awareness & Education

0by25 will promote increased awareness of AKI across the global healthcare community, predominantly through education and training. Targeted information and educational materials will be developed for a broad range of audiences, including healthcare professionals, patients and governments.

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0by25 will work with those most affected to develop a sustainable infrastructure to enable “need driven” approaches to education, training and care delivery. Through pilot projects, 0by25 will implement globally applicable strategies that permit timely diagnosis and treatment of AKI for patients with potentially reversible diseases.

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AKI is preventable 
and treatable

AKI is characterised by an abrupt loss of kidney function. If left untreated, the condition has a high risk of multiple organ failure and, potentially, death. AKI is a major global healthcare challenge with an estimated 13.3 million cases every year. The situation is particularly tragic in developing countries, where the annual burden of AKI is estimated to be 11.3 million cases. AKI is often preventable and treatable with few, if any, long-term health consequences. However, the lack of early identification and treatment in many countries means that patients often don’t receive essential care before it is too late.

Boy Smiling
Outreach in El Salvador

The mission

The 0by25 initiative aims to eliminate preventable deaths from Acute Kidney Injury (AKI) worldwide by 2025. To achieve this ambitious goal, the mission is to call for globally applicable strategies that permit timely diagnosis and treatment of AKI for patients with potentially reversible diseases. This is a global initiative with a strong emphasis on developing countries in Africa, Asia, and Latin America with disadvantaged populations and poor access to care.

Focus: Global Snapshot

One of the first major projects to be launched under the 0by25 initiative will be the “GLOBAL SNAPSHOT”. This is a prospective, cross-sectional study aimed at establishing the incidence of Acute Kidney Injury (AKI) in different settings around the world. The web-based data collection was conducted from 29 September 2014 to 7 December 2014.

The Global Snapshot is now closed.

Thanks to the kind support of over 320 participating centers in more than 72 countries, we are currently analysing the data for over 4000 pediatric and adult patients, with significant new information coming from Africa, Asia, and Latin America.

Some initial Global Snapshot results were unveiled at ISN World Congress of Nephrology during a Special Session entitled "The 0by25 Initiative: progress and achievements so far" which took place on Saturday 14 March 2015. 

Further in-depth analysis of the Global Snapshot data is currently under way and official publication of the results of the study is expected to take place in the course of 2015. Stay tuned!


ISN is pleased to announce the winners of the iPad Prize Draw organised to thank all of our Global Snapshot participants for their support and excellent contribution! 


Dr. R. Evans (UK), Dr. Gunlapalli (India), Dr. S. Martin (Argentina), Nurse L. Dill (U.S.A.) Dr. J. Prakash (India). 

Congratulations to our iPad winners!


Community work in Nepal